咖啡为何有益健康？科学家发现咖啡中的化合物通过激活NR4A1受体帮助身体对抗压力和衰老
New findings from the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) point to one possible answer. Researchers found that certain compounds in coffee may activate NR4A1, a receptor that is becoming increasingly important in studies of aging, stress responses and disease.
The research, recently published in Nutrients, offers one of the first direct links between coffee compounds and NR4A1. That connection may help explain some of the broad health effects associated with drinking coffee.
“Coffee has well-known health-promoting properties,” said Dr. Stephen Safe, distinguished professor and Sid Kyle Endowed Chair in Veterinary Toxicology in VMBS’ Department of Veterinary Physiology and Pharmacology. “What we’ve shown is that some of those effects may be linked to how coffee compounds interact with this receptor, which is involved in protecting the body from stress-induced damage.”
How NR4A1 Helps Protect the Body
NR4A1 is part of a group of nuclear receptors that help control gene activity when the body is exposed to stress or tissue damage.
In earlier research, Safe and his collaborators described NR4A1 as a “nutrient sensor,” meaning that it can respond to dietary compounds and contribute to the body’s ability to remain healthy with age.
原文来源：https://www.sciencedaily.com/releases/2026/07/260719035927.htm | 科学小舟·新科学 转载